Yoshida J, Tanimura A, Yamashita H, Matsuo K
Department of Surgery, Shimonoseki City Hospital, Shimonoseki, Japan.
Thyroid. 1999 Apr;9(4):401-4. doi: 10.1089/thy.1999.9.401.
A 22-year-old male presented with a 1-year history of a right anterior neck mass. He did not have gastrointestinal cancer. Laboratory examination revealed an elevated serum thyroglobulin level of 120 ng/mL. The neck lesion showed poor uptake on 99mTc scan, but enhanced uptake on 201T1 scan. The patient underwent a hemithyroidectomy; the cut surface of the 7 x 3.5 cm lesion was solid and tanned orange. Postoperatively the serum thyroglobulin level decreased to 26 ng/mL. Microscopy of the tumor showed signet ring cells and microfollides, both of which were positive for mucicarmin and alcian Blue. A small percentage of the follicles were positive for thyroglobulin and periodic acid-Schiff. Our literature search detected 18 patients with signet ring cell lesions positive for thyroglobulin, but none had characteristics similar to ours showing predominance of mucin and poor staining for thyroglobulin.
一名22岁男性，有右前颈部肿块1年病史。他没有胃肠道癌症。实验室检查显示血清甲状腺球蛋白水平升高至120 ng/mL。颈部病变在99mTc扫描中摄取不佳，但在201T1扫描中摄取增强。患者接受了半甲状腺切除术；7×3.5 cm病变的切面坚实，呈棕褐色。术后血清甲状腺球蛋白水平降至26 ng/mL。肿瘤显微镜检查显示印戒细胞和微滤泡，两者对黏液卡红和阿尔辛蓝均呈阳性。一小部分滤泡对甲状腺球蛋白和过碘酸希夫呈阳性。我们的文献检索发现18例甲状腺球蛋白阳性的印戒细胞病变患者，但没有一例具有与我们相似的特征，即黏液占优势且甲状腺球蛋白染色不佳。
