Gulwani Hanni, Chopra P
Department of Histopathology, Sir Ganga Ram Hospital, New Delhi 110 060, India.
Indian J Pathol Microbiol. 2008 Oct-Dec;51(4):507-8. doi: 10.4103/0377-4929.43742.
Signet ring cell adenoma of the thyroid, though rare, is well documented. This change is chiefly due to intracellular accumulation of thyroglobulin that appears mucinous. Awareness of this entity is important as it may closely simulate a metastatic mucin-secreting signet ring cell carcinoma. Although the mucinous material in signet ring cells has been reported to stain positive with thyroglobulin, in some cases it may not be so. We herein describe a rare case of a 46-year-old man who was hypothyroid and the mass removed from the thyroid showed a mucin-producing signet ring cell adenoma of the thyroid.
甲状腺印戒细胞腺瘤虽罕见，但文献记载充分。这种改变主要是由于甲状腺球蛋白在细胞内积聚，呈黏液样外观。认识到这一实体很重要，因为它可能酷似转移性分泌黏液的印戒细胞癌。尽管有报道称印戒细胞中的黏液物质甲状腺球蛋白染色呈阳性，但在某些情况下可能并非如此。我们在此描述一例罕见病例，一名46岁甲状腺功能减退男性，从甲状腺切除的肿物为甲状腺黏液生成性印戒细胞腺瘤。
