Yabe Y, Kashiwakura Y, Tanaka H, Hasegawa M, Tsuzuku A, Yoshimura S
Recent Adv Stud Cardiac Struct Metab. 1976;12:415-23.
Myocardial infarction was produced in dogs, and the changes in nucleic acid synthetic activity were investigated quantitatively by microspectrophotometer in the myocardial cells as time progressed. DNA value, immediately after infarction, was greatly increased in comparison to that of the control group. At two weeks after infarction the value had increased to the highest level. After this point the value decreased, and, in 12 weeks, the mean value was back to the control level. Changes in RNA followed a pattern similar to DNA changes. The mechanism of the repair process of myocardial infarction was investigated.
在犬身上制造心肌梗死，并随着时间的推移，用显微分光光度计对心肌细胞中核酸合成活性的变化进行定量研究。梗死即刻，DNA值与对照组相比大幅增加。梗死后两周，该值升至最高水平。此后该值下降，在12周时，平均值恢复到对照水平。RNA的变化模式与DNA变化相似。对心肌梗死的修复过程机制进行了研究。
