Meerson F Z, Vasil'ev V K, Dosmagambetova R S
Biull Eksp Biol Med. 1982 Jun;93(6):57-60.
DNA damage and repair in the nonischemic area of the heart were analyzed after experimental myocardial infarction to evaluate the effect on these processes of the beta-blocker inderal and lipid peroxidation inhibitor ionol. It was found that in the nonischemic area of the heart, DNA damage was manifested by the decreased polymerism averted to a significant degree by inderal and ionol which interfered with postinfarction activation of lipid peroxidation. Accordingly, inderal and, to a greater degree, ionol reduced postinfarction activation of DNA repair synthesis in the nonischemic area of the heart.
在实验性心肌梗死后，对心脏非缺血区域的DNA损伤与修复进行了分析，以评估β受体阻滞剂心得安和脂质过氧化抑制剂乙氧喹对这些过程的影响。结果发现，在心脏非缺血区域，DNA损伤表现为聚合作用降低，心得安和乙氧喹能在很大程度上避免这种情况，它们可干扰梗死后脂质过氧化的激活。相应地，心得安以及在更大程度上乙氧喹可降低心脏非缺血区域梗死后DNA修复合成的激活。
