Ogasawara K, Mizoi K, Fujiwara S, Yoshimoto T
Department of Neurosurgery, Kohnan Hospital, Japan.
AJNR Am J Neuroradiol. 1999 Apr;20(4):626-8.
Two patients with a cerebral embolism were evaluated by using both 99mTc-ethyl cysteinate dimer (ECD, or Bicisate) and 99mTc-hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography (SPECT). In one patient, 99mTc-ECD SPECT images revealed hypoactivity in a reflow hyperemic area where an infarct was seen later on CT scans. In another patient, a reperfused area showed hyperactivity on 99mTc-ECD SPECT without any abnormality on follow-up CT. 99mTc-ECD represents a potential agent with which to evaluate cerebral tissue viability in early reperfusion after ischemia.
两名脑栓塞患者接受了99m锝-乙基半胱氨酸二聚体（ECD，或比西酯）和99m锝-六甲基丙烯胺肟（HMPAO）单光子发射计算机断层扫描（SPECT）评估。在一名患者中，99m锝-ECD SPECT图像显示再灌注充血区域存在放射性减低，随后CT扫描发现该区域有梗死灶。在另一名患者中，再灌注区域在99m锝-ECD SPECT上显示放射性增高，随访CT未见任何异常。99m锝-ECD是一种在缺血后早期再灌注时评估脑组织活力的潜在药物。
