脑桥梗死后中枢性疼痛与阿片受体结合变化有关：一项使用11C-二丙诺啡的正电子发射断层扫描研究。
Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-diprenorphine.
作者信息
Willoch F, Tölle T R, Wester H J, Munz F, Petzold A, Schwaiger M, Conrad B, Bartenstein P
机构信息
Department of Nuclear Medicine, Technische Universität München, Germany.
出版信息
AJNR Am J Neuroradiol. 1999 Apr;20(4):686-90.
Abstract
Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C-diprenorphine PET provides unique information for the understanding of central poststroke pain.
摘要
我们使用18F-氟脱氧葡萄糖和11C-二丙诺啡正电子发射断层扫描（PET），对一名在小的脑桥出血性梗死发作后出现中枢性卒中后疼痛的患者的葡萄糖代谢和阿片受体结合变化进行了研究。与正常数据库相比，在症状对侧的外侧皮质表面，11C-二丙诺啡结合减少比代谢减低更为明显，并且在疼痛相关的中枢结构中观察到示踪剂之间存在异常分布差异。这些结果表明，11C-二丙诺啡PET为理解中枢性卒中后疼痛提供了独特的信息。
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