Suárez H, Mut F, Lago G, Silveira A, De Bellis C, Velluti R, Pedemonte M, Svirsky M
Laboratory of Audiology and Vestibular Research, School of Medicine, Uruguay.
Acta Otolaryngol. 1999 Mar;119(2):239-43. doi: 10.1080/00016489950181747.
Five postlingually deaf patients (age range 28-58 years) with multichannel cochlear implants were examined with single photon emission tomography (SPECT) (triple-head rotating gamma camera). Changes in the regional cerebral blood flow (rCBF) after intravenous administration of technetium-99m ethyl cysteinate dimer (Tc-99m ECD) were assessed through a stimulation paradigm, consisting of: i) click stimuli (75 dB SPL) in the ear that was to be implanted, 2 weeks before surgery; ii) stimulation with the same click, one month after initial fitting; iii) stimulation with hearing sequential Spanish sentences one month after initial fitting. The results showed a significant increase in the rCBF in the primary left auditory area and in the right auditory cortex, in conditions ii) and iii). The rCBF also showed a significant asymmetrical increase in the frontal lobes when the patient was hearing sequential sentences (condition iii)) with asymmetrical distribution among patients. These results are discussed, principally the correlation between speech discrimination scores and the rCBF distribution in the frontal and temporal lobes.
对5名使用多通道人工耳蜗植入的语后聋患者（年龄范围28 - 58岁）进行了单光子发射断层扫描（SPECT）检查（三头旋转γ相机）。通过一种刺激模式评估静脉注射锝-99m半胱氨酸乙酯二聚体（Tc-99m ECD）后局部脑血流（rCBF）的变化，该刺激模式包括：i）手术前2周，对拟植入耳进行咔哒声刺激（75 dB SPL）；ii）初次调试后1个月，用相同的咔哒声进行刺激；iii）初次调试后1个月，用连贯的西班牙语句子进行刺激。结果显示，在情况ii）和iii）下，左侧初级听觉区和右侧听觉皮层的rCBF显著增加。当患者听连贯句子时（情况iii）），额叶的rCBF也显示出显著的不对称增加，且患者之间分布不对称。对这些结果进行了讨论，主要讨论了言语辨别分数与额叶和颞叶rCBF分布之间的相关性。
