肉瘤样集合管癌

Sarcomatoid collecting duct carcinoma.

作者信息

Fukunaga M

机构信息

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

Arch Pathol Lab Med. 1999 Apr;123(4):338-41. doi: 10.5858/1999-123-0338-SCDC.

DOI:10.5858/1999-123-0338-SCDC

PMID:10320148

Abstract

BACKGROUND

Collecting duct carcinoma has recently been recognized as a distinct entity among renal cell carcinomas and shows aggressive clinical behavior.

DESIGN

A fatal case of collecting duct carcinoma with sarcomatoid features in an 80-year-old man is described, and the results of immunohistochemistry and flow cytometric analysis are presented.

RESULTS

The tumor, which was white and had infiltrating margins in the cortex and medulla, consisted of adenocarcinomatous and sarcomatous components. The adenocarcinomatous component was characterized by tubular arrangement of atypical cells with high-grade nuclear features and desmoplastic stroma. The sarcomatous component had a malignant fibrous histocytoma-like appearance. The tumor cells in the adenocarcinomatous area were positive for cytokeratin 19, Ulex europaeus agglutinin I, peanut agglutinin, and soybean agglutinin. The tumor was DNA diploid. The patient died of disease 3 months after diagnosis.

CONCLUSION

This study suggests that sarcomatoid collecting duct carcinoma may be one of the most aggressive tumors of the kidney.

摘要

背景

集合管癌最近被认为是肾细胞癌中的一种独特类型，且具有侵袭性的临床行为。

设计

描述了一名80岁男性患有具有肉瘤样特征的集合管癌的致命病例，并展示了免疫组化和流式细胞术分析结果。

结果

肿瘤呈白色，在皮质和髓质中边界浸润，由腺癌和肉瘤成分组成。腺癌成分的特征为具有高级别核特征的非典型细胞呈管状排列以及促纤维组织增生性间质。肉瘤成分具有恶性纤维组织细胞瘤样外观。腺癌区域的肿瘤细胞细胞角蛋白19、欧洲荆豆凝集素I、花生凝集素和大豆凝集素呈阳性。肿瘤为DNA二倍体。患者在诊断后3个月死于该疾病。