Knyihár E, Csillik B
Acta Biol Acad Sci Hung. 1976;27(4):299-308.
Transection, crush or local colchicine treatment of a peripheral nerve induces degenerative atrophy of central terminals of primary sensory neurons in the Rolando substance of the rat spinal cord. In addition to osmiophilic alterations that occur in the course of degenerative processes in general, degenerative atrophy is characterized by the appearance of spectacular labyrinthine formations. Electron-microscopic analysis reveals that these consist of flattened axonal profiles. Axonal labyrinths are interpreted as signs of futile regenerative efforts of axon terminals undergoining degenerative atrophy. Labyrinths disappear from the Rolando substance several months after peripheral nerve injury, when degenerative atrophy of the central terminal is replaced by regenerative proliferation.
对大鼠脊髓罗氏胶质区的初级感觉神经元的中枢终末而言，外周神经的横断、挤压或局部秋水仙碱处理会诱发退行性萎缩。除了在一般退行性过程中出现的嗜锇性改变外，退行性萎缩的特征是出现壮观的迷路样结构。电子显微镜分析显示，这些结构由扁平的轴突轮廓组成。轴突迷路被解释为正在经历退行性萎缩的轴突终末徒劳的再生努力的迹象。在外周神经损伤数月后，当中枢终末的退行性萎缩被再生性增殖取代时，迷路样结构从罗氏胶质区消失。
