Csillik B, Knyihár E, Jójárt I, Elshiekh A A, Pór I
Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):467-84.
Short-term perineural application of a microtubule inhibitor around a peripheral nerve induces degenerative atrophy of primary central nociceptive terminals in the Rolando substance. Consequences of the local microtubule inhibitor treatment are identical, both at light- and electron microscopic levels, with those that follow transection of a peripheral nerve. Degenerative atrophy in the Rolando substance is due to arrested axoplasmic transport in, and not to Wallerian degeneration of, the peripheral axons since (1) locally applied vinblastine and vincristone do not induce peripheral degeneration at all and (2) even though local colchicine treatment may cause Wallerian degeneration of thick myelinated axons, thin Adelta and C fibers do not undergo degeneration after colchicine treatment. The intriguing possibility to use this approach in the treatment of intractable pain is discussed.
在周围神经周围短期应用微管抑制剂会导致脊髓后角原发性中枢伤害性感受神经元终末发生退行性萎缩。局部微管抑制剂治疗的结果，在光学显微镜和电子显微镜水平上，与周围神经横断后的结果相同。脊髓后角的退行性萎缩是由于外周轴突内轴浆运输停滞，而非外周轴突的华勒氏变性，因为：（1）局部应用长春花碱和长春新碱根本不会诱导外周变性；（2）尽管局部秋水仙碱治疗可能会导致粗大的有髓轴突发生华勒氏变性，但细的Aδ纤维和C纤维在秋水仙碱治疗后不会发生变性。文中讨论了使用这种方法治疗顽固性疼痛的有趣可能性。
