Gras-Masse H, Georges B, Estaquier J, Tranchand-Bunel D, Tartar A, Druilhe P, Auriault C
Laboratoire de Synthèse, Structure et Fonction des Biomolécules, UMR 8525, CNRS-Université Lille II-Institut Pasteur de Lille, 1 rue Calmette, 59021, Lille, France.
Curr Opin Immunol. 1999 Apr;11(2):223-8. doi: 10.1016/s0952-7915(99)80038-7.
Many recent studies have demonstrated the flexibility of epitope recognition by the immune system. This can be explored using a particular type of combinatorial peptide library, termed as 'convergent', consisting essentially of closely related molecular species; from this a fuzzy set can be constructed, which comprises several variants of a peptide that would act in synchrony to represent a model antigen and its recognition by the immune system.
许多近期研究已证明免疫系统识别表位的灵活性。这可以通过使用一种特殊类型的组合肽库来探索，这种库被称为“趋同”库，主要由密切相关的分子种类组成；由此可以构建一个模糊集，它包含一种肽的几种变体，这些变体将协同作用以代表一种模型抗原及其被免疫系统的识别情况。
