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Evaluation of an Epstein-Barr virus (EBV) immunoglobulin M enzyme-linked immunosorbent assay using a synthetic convergent peptide library, or mixotope, for diagnosis of primary EBV infection.使用合成的汇聚肽文库（或混合表位）评估爱泼斯坦-巴尔病毒（EBV）免疫球蛋白M酶联免疫吸附测定法用于原发性EBV感染的诊断。
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[A comparison of the detection of IgM antibodies against the viral capsid antigen (VCA) of EBV (Epstein-Barr virus) in various groups of patients, using indirect immunofluorescence, indirect ELISA and reverse ELISA. Study of the diagnostic efficacy of the anti-VCA EBV IgM ELISA-VIDITEST kit].[采用间接免疫荧光法、间接酶联免疫吸附测定法和反向酶联免疫吸附测定法对不同患者组中针对EB病毒（Epstein-Barr病毒）病毒衣壳抗原（VCA）的IgM抗体进行检测的比较。抗VCA EBV IgM酶联免疫吸附测定试剂盒（ELISA-VIDITEST）的诊断效能研究]
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本文引用的文献

1
Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses.用于引发或识别特定免疫反应的趋同肽文库，即混合表位。
Curr Opin Immunol. 1999 Apr;11(2):223-8. doi: 10.1016/s0952-7915(99)80038-7.
2
Detection of human antibodies using "convergent" combinatorial peptide libraries or "mixotopes" designed from a nonvariable antigen: application to the EBV viral capsid antigen p18.利用“收敛性”组合肽文库或由非可变抗原设计的“混合表位”检测人抗体：应用于EBV病毒衣壳抗原p18
J Pept Res. 1998 Dec;52(6):495-508. doi: 10.1111/j.1399-3011.1998.tb01254.x.
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Difficulties with the serologic diagnosis of infectious mononucleosis: a review of the RCPA quality assurance programs.
Pathology. 1996 Aug;28(3):270-6. doi: 10.1080/00313029600169144.
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Identification and molecular characterization of two diagnostically relevant marker proteins of the Epstein-Barr virus capsid antigen complex.爱泼斯坦-巴尔病毒衣壳抗原复合体两种诊断相关标志物蛋白的鉴定及分子特征分析
J Med Virol. 1993 Jun;40(2):161-9. doi: 10.1002/jmv.1890400215.
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Comparative evaluation of nine kits for rapid diagnosis of infectious mononucleosis and Epstein-Barr virus-specific serology.九种传染性单核细胞增多症快速诊断试剂盒及爱泼斯坦-巴尔病毒特异性血清学检测试剂盒的比较评估
J Clin Microbiol. 1994 Jan;32(1):259-61. doi: 10.1128/jcm.32.1.259-261.1994.
6
Localization and diagnostic application of immunodominant domains of the BFRF3-encoded Epstein-Barr virus capsid protein.EB病毒衣壳蛋白BFRF3编码的免疫显性结构域的定位及诊断应用
J Infect Dis. 1994 Jul;170(1):13-9. doi: 10.1093/infdis/170.1.13.
7
False positive EBNA IgM and IgG antibody tests for infectious mononucleosis in children.儿童传染性单核细胞增多症EBNA IgM和IgG抗体检测的假阳性结果
Pediatrics. 1994 Dec;94(6 Pt 1):892-4.
8
Limitations of available tests for diagnosis of infectious mononucleosis.传染性单核细胞增多症现有诊断检测方法的局限性。
J Clin Microbiol. 1983 Apr;17(4):619-24. doi: 10.1128/jcm.17.4.619-624.1983.
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Infectious mononucleosis.传染性单核细胞增多症
Semin Hematol. 1988 Jul;25(3):261-8.
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Antibody response against the Epstein-Barr virus-coded nuclear antigen2 (EBNA2) in different groups of individuals.不同人群中针对爱泼斯坦-巴尔病毒编码的核抗原2（EBNA2）的抗体反应。
Int J Cancer. 1987 Sep 15;40(3):349-53. doi: 10.1002/ijc.2910400311.

使用合成的汇聚肽文库（或混合表位）评估爱泼斯坦-巴尔病毒（EBV）免疫球蛋白M酶联免疫吸附测定法用于原发性EBV感染的诊断。

Evaluation of an Epstein-Barr virus (EBV) immunoglobulin M enzyme-linked immunosorbent assay using a synthetic convergent peptide library, or mixotope, for diagnosis of primary EBV infection.

作者信息

Tranchand-Bunel D, Gras-Masse H, Bourez B, Dedecker L, Auriault C

机构信息

Laboratoire d'Immunologie Cellulaire, CNRS UMR 8527, Institut Pasteur de Lille, 59019 Lille, France.

出版信息

J Clin Microbiol. 1999 Jul;37(7):2366-8. doi: 10.1128/JCM.37.7.2366-2368.1999.

DOI:10.1128/JCM.37.7.2366-2368.1999
PMID:10364618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC85167/
Abstract

An immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) was developed by using a 24-amino-acid peptide of the 18-kDa Epstein-Barr virus (EBV) viral capsid antigen (VCAp18). IgM detection was increased by 23% by using this antigen. Detection of IgM antibodies to the EBV proteins in the new ELISA was 100% specific and 95% sensitive.

摘要

通过使用18 kDa爱泼斯坦-巴尔病毒（EBV）病毒衣壳抗原（VCAp18）的24个氨基酸肽段，开发了一种免疫球蛋白M（IgM）酶联免疫吸附测定（ELISA）。使用该抗原使IgM检测率提高了23%。新ELISA中针对EBV蛋白的IgM抗体检测特异性为100%，敏感性为95%。