Carlson M
Departments of Genetics and Development and Microbiology, Columbia University, HHSC 922, Box 136, 701 W. 168th Street, New York, NY 10032, USA.
Curr Opin Microbiol. 1999 Apr;2(2):202-7. doi: 10.1016/S1369-5274(99)80035-6.
The Snf1 protein kinase is a central component of the signaling pathway for glucose repression in yeast. Recent studies have addressed the regulation of Snf1 kinase activity and elucidated mechanisms by which Snf1 controls repression and activation of glucose-repressed genes. Important advances include evidence that Snf1 regulates the localization of the Mig1 repressor and that Snf1 functions at multiple points to control Cat8 and Sip4, the activators of gluconeogenic genes.
Snf1蛋白激酶是酵母中葡萄糖阻遏信号通路的核心组成部分。最近的研究探讨了Snf1激酶活性的调节，并阐明了Snf1控制葡萄糖阻遏基因的阻遏和激活的机制。重要进展包括有证据表明Snf1调节Mig1阻遏物的定位，以及Snf1在多个位点发挥作用以控制糖异生基因的激活剂Cat8和Sip4。
