酿酒酵母中的RNA解旋：DEAD-box蛋白及相关家族

Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.

作者信息

de la Cruz J, Kressler D, Linder P

机构信息

Instituto de Bioqu mica Vegetal y Fotos ntesis, Centro Isla de la Cartuja, Universidad de Sevilla-CSIC, Américo Vespucio s/n, 41092 Sevilla, Spain.

出版信息

Trends Biochem Sci. 1999 May;24(5):192-8. doi: 10.1016/s0968-0004(99)01376-6.

DOI:10.1016/s0968-0004(99)01376-6

PMID:10322435

Abstract

Members of the RNA-helicase family are defined by several evolutionary conserved motifs. They are found in all organisms - from bacteria to humans - and many viruses. The minimum number of RNA helicases present within a eukaryotic cell can be predicted from the complete sequence of the Saccharomyces cerevisiae genome. Recent progress in the functional analysis of various family members has given new insights into, and confirmed the significance of these proteins for, most cellular RNA metabolic processes.

摘要

RNA解旋酶家族的成员由几个进化上保守的基序所定义。它们存在于从细菌到人类的所有生物体以及许多病毒中。真核细胞中RNA解旋酶的最小数量可以根据酿酒酵母基因组的完整序列来预测。最近在各种家族成员功能分析方面取得的进展为大多数细胞RNA代谢过程带来了新的见解，并证实了这些蛋白质的重要性。