Nama V, Kozlowski J K, Hamvas A
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Arch Dis Child Fetal Neonatal Ed. 1999 Jan;80(1):F26-9. doi: 10.1136/fn.80.1.f26.
To determine whether abnormal transvascular protein flux can be measured with positron emission tomography (PET) in neonates with respiratory distress syndrome (RDS).
Fourteen infants with normal gas exchange (non-RDS group) underwent one PET measurement and 12 infants with RDS (the RDS group) underwent two measurements of protein flux, as determined by the pulmonary transcapillary escape rate for 68Gallium labelled transferrin (PTCER).
The mean PTCER for the RDS infants (132 +/- 39 10(-4)/min) was significantly greater than that for infants without RDS (75 +/- 27 10(-4)/min). PTCER did not change between measurements in the infants with RDS, including five who received and responded to surfactant replacement between the two scans.
Increased transvascular flux of large molecular weight proteins complicates RDS in preterm infants. PET provides a tool with which to evaluate the processes that contribute to pulmonary dysfunction in neonates.
确定正电子发射断层扫描（PET）能否用于测量呼吸窘迫综合征（RDS）新生儿的经血管蛋白异常通量。
对14名气体交换正常的婴儿（非RDS组）进行了一次PET测量，对12名RDS婴儿（RDS组）进行了两次蛋白通量测量，蛋白通量通过68镓标记转铁蛋白的肺毛细血管逃逸率（PTCER）来确定。
RDS婴儿的平均PTCER（132±39×10⁻⁴/分钟）显著高于无RDS的婴儿（75±27×10⁻⁴/分钟）。RDS婴儿在两次测量之间PTCER没有变化，其中包括5名在两次扫描之间接受了表面活性剂替代治疗并产生反应的婴儿。
大分子蛋白的经血管通量增加使早产儿的RDS病情复杂化。PET提供了一种工具，可用于评估导致新生儿肺功能障碍的相关过程。
