Morlion B, Ebner E, Weber A, Finke W, Puchstein C
Department of Anaesthesiology and Intensive Care, Marienhospital Herne, Ruhr-University of Bochum, Germany.
Br J Anaesth. 1999 Jan;82(1):52-5. doi: 10.1093/bja/82.1.52.
We have examined the influence of bolus size on efficacy, opioid consumption, side effects and patient satisfaction during i.v. patient-controlled analgesia (PCA) in 60 patients (ASA I-II, aged 32-82 yr) after abdominal surgery. Patients were allocated randomly, in a double-blind manner, to receive PCA with a bolus dose of either piritramide 0.75 mg or 1.5 mg (lockout 5 min) for postoperative pain control. Mean 24 h piritramide consumption differed significantly between groups (11.4 (SD 5.8) mg vs 22.5 (18.3) mg; P = 0.001). There were no significant differences in the number of applied bolus doses, pain scores, pain relief (VAS), sedation, nausea, pruritus and patient satisfaction. We conclude that a PCA regimen with a bolus dose of piritramide 0.75 mg and a lockout time of 5 min was effective in the treatment of postoperative pain, but did not reduce the occurrence of side effects.
我们研究了在60例腹部手术后患者（ASA I-II级，年龄32 - 82岁）静脉自控镇痛（PCA）期间，推注剂量对疗效、阿片类药物消耗量、副作用及患者满意度的影响。患者被随机、双盲分配，接受PCA治疗，推注剂量分别为哌替啶0.75 mg或1.5 mg（锁定时间5分钟），用于术后疼痛控制。两组间24小时哌替啶平均消耗量差异显著（11.4（标准差5.8）mg对22.5（18.3）mg；P = 0.001）。在推注剂量次数、疼痛评分、疼痛缓解程度（视觉模拟评分法）、镇静、恶心、瘙痒及患者满意度方面，两组无显著差异。我们得出结论，推注剂量为0.75 mg哌替啶且锁定时间为5分钟的PCA方案在治疗术后疼痛方面有效，但并未减少副作用的发生。
