Anstead G M
Department of Internal Medicine, University of Texas Health Science Center, San Antonio, USA.
Adv Wound Care. 1998 Oct;11(6):277-85.
Glucocorticoids (corticosteroids) cause dehiscence of surgical incisions, increased risk of wound infection, and delayed healing of open wounds. They produce these effects by interfering with inflammation, fibroblast proliferation, collagen synthesis and degradation, deposition of connective tissue ground substances, angiogenesis, wound contraction, and re-epithelialization. These actions are mediated by the antagonism of various growth factors and cytokines. Vitamin A restores the inflammatory response and promotes epithelialization and the synthesis of collagen and ground substances. However, vitamin A does not reverse the detrimental effects of glucocorticoids on wound contraction and infection. In this paper, the known mechanisms of the interaction of glucocorticoids and retinoids are reviewed. The mutually inhibitory interplay between glucocorticoids and retinoids may serve to regulate the processes of inflammation, immunity, and connective tissue repair.
糖皮质激素（皮质类固醇）会导致手术切口裂开、伤口感染风险增加以及开放性伤口愈合延迟。它们通过干扰炎症、成纤维细胞增殖、胶原蛋白合成与降解、结缔组织基质沉积、血管生成、伤口收缩和再上皮化来产生这些影响。这些作用是由多种生长因子和细胞因子的拮抗作用介导的。维生素A可恢复炎症反应，促进上皮化以及胶原蛋白和基质的合成。然而，维生素A并不能逆转糖皮质激素对伤口收缩和感染的有害影响。本文综述了糖皮质激素与类视黄醇相互作用的已知机制。糖皮质激素和类视黄醇之间相互抑制的相互作用可能有助于调节炎症、免疫和结缔组织修复过程。
