Gallo M, Marquez S L, Ballesteros M A, Maldonado A
Department of Experimental Psychology and Physiology of Behavior, University of Granada, Spain.
Neurosci Lett. 1999 Apr 9;265(1):57-60. doi: 10.1016/s0304-3940(99)00209-8.
The role of the parabrachial area in conditioned taste aversion (CTA) induced by motion-sickness was studied in male Wistar rats. In the first experiment, one-trial conditioned taste aversion, to a 0.5% decaffeinated coffee solution, was induced by 30 min of vertical rotatory motion (80 rev./min) in intact rats. In the second experiment, reversible blockade of the neural activity in various brainstem sites was induced by bilateral intracerebral injections of tetrodotoxin (TTX) (10 ng/microl) after conditioning. Blockade of the parabrachial area, but neither A8 nor lateral vestibular nucleus, disrupted the acquisition of (CTA). The results are discussed in terms of an associative role of the parabrachial area in body rotation-induced taste aversion learning, as the area was intact during sensory processing and testing.
在雄性Wistar大鼠中研究了臂旁区在晕动病诱发的条件性味觉厌恶（CTA）中的作用。在第一个实验中，通过在完整大鼠中进行30分钟的垂直旋转运动（80转/分钟），诱导对0.5%脱咖啡因咖啡溶液的单次条件性味觉厌恶。在第二个实验中，在条件化后通过双侧脑内注射河豚毒素（TTX）（10纳克/微升）诱导各种脑干部位神经活动的可逆性阻断。臂旁区的阻断，而不是A8或外侧前庭核的阻断，破坏了（CTA）的获得。鉴于在感觉处理和测试过程中该区域是完整的，因此从臂旁区在身体旋转诱发的味觉厌恶学习中的关联作用方面对结果进行了讨论。
