Ribarova F
Probl Khig. 1976;2:55-61.
Changes in LDH, SDH, MDH and G-6-PDH activity in the liver of white male rats are studied within 2, 4, 8, 15, 30, 60 and 90 days of treatment with 1/10 and 1/50 LD50 and after 15 days recovery period following the 90-day-long treatment. The animals are divided up into three groups as follows: group one--treated with 1/10 LD50, group two--with 1/50 LD50, and a control group treated with vegetable oil solvent at the respective days. The findings show that changes in enzyme activity are comparatively one-way in terms of duration of the treatment. In the early days of the experiment, a reliable increase is noted followed by a normalization of the values and reliable reduction. At ninety days, and after the recovery period is over, the activities of all five enzymes do not differ from those in the control groups. The most clearly outlined changes are recorded in SDH, and the slightest--in MDH. The analysis of the picture obtained shows that in all instances it is a matter of reversible changes.
研究了用1/10和1/50 LD50对雄性白色大鼠进行处理2、4、8、15、30、60和90天以及在90天长期处理后的15天恢复期内，其肝脏中乳酸脱氢酶（LDH）、琥珀酸脱氢酶（SDH）、苹果酸脱氢酶（MDH）和葡萄糖-6-磷酸脱氢酶（G-6-PDH）活性的变化。将动物分为三组如下：第一组用1/10 LD50处理，第二组用1/50 LD50处理，对照组在相应天数用植物油溶剂处理。研究结果表明，就处理持续时间而言，酶活性的变化相对呈单向性。在实验初期，酶活性显著增加，随后数值恢复正常并显著降低。在90天时以及恢复期结束后，所有五种酶的活性与对照组无差异。最明显的变化记录在SDH中，最不明显的变化记录在MDH中。对所获得结果的分析表明，在所有情况下都是可逆变化。
