Apostolov I, Riboarova F
Probl Khig. 1976;2:169-73.
The influence of 1/50 and 1/10 LD50 of the monomethylcarbamate insecticide Propoxur (Baygon) on the lysosome enzyme beta-N-acetylglucose-aminidase serum activity is studied in white rats upon daily administration per os, over a period of 2, 4, 8, 15, 30, 60 and 90 days. A statistically significant increase of the enzyme activity is recorded at 15 days after introduction of 1/50 LD50, and at 15 and 30 days after 1/10 LD50 administration, followed by a reduction of the activity and returning to normal values. In all likelihood, the harmful effect of Propoxur on the lysosome and cellular membrane decreases after the 15th day because of activation of the microsome enzymes which, in turn, speed up the process of rendering innocuous the insecticide administered.
研究了氨基甲酸酯类杀虫剂残杀威（拜耳驱虫菊酯）的1/50和1/10半数致死剂量（LD50）对白色大鼠血清溶酶体酶β-N-乙酰氨基葡萄糖苷酶活性的影响。每天经口给药，持续2、4、8、15、30、60和90天。在引入1/50 LD50后15天以及1/10 LD50给药后15天和30天，记录到酶活性有统计学意义的增加，随后活性降低并恢复到正常值。很可能在第15天后，残杀威对溶酶体和细胞膜的有害作用降低，这是因为微粒体酶被激活，进而加速了所施用杀虫剂的无害化过程。
