Apostolov I, Ribarova F, Pramatarova V
Probl Khig. 1975;1:207-10.
The effect of repeated peroral introduction (4 times) of 1/4 and 1/20 LD50 of monomethylcarbamate insecticide Propoxur (Baygon) on the activity of two lysosomal enzymes (beta-N-acetylglucosaminidase and alpha-mannosidase) is studied in the serum of white male rats with starting weight 300 g. Upon using the higher dose, a statistically significant rise (p less than 0.02) of the activity of either of the enzymes is established. The results obtained are interpreted as a sign of impaired permeability of the lysosomal and cell membrane.
研究了对初始体重为300克的雄性白色大鼠血清中两种溶酶体酶（β-N-乙酰氨基葡萄糖苷酶和α-甘露糖苷酶）的活性，经口重复引入（4次）1/4和1/20 LD50的氨基甲酸酯类杀虫剂残杀威（拜戈）的影响。使用较高剂量时，两种酶的活性均出现统计学上的显著升高（p<0.02）。所得结果被解释为溶酶体膜和细胞膜通透性受损的迹象。
