Glasser A, Kaufman P L
College of Optometry, University of Houston, Texas 77004, USA.
Ophthalmology. 1999 May;106(5):863-72. doi: 10.1016/S0161-6420(99)00502-3.
To study the accommodative mechanism in primates using monkeys, in light of a recently proposed novel accommodative mechanism in primates and a concomitant controversial surgical procedure for the reversal of presbyopia,
Experimental study.
Accommodation was induced by stimulation of an electrode surgically implanted in the midbrain and by topical ocular application of muscarinic agonists. Pharmacologic disaccommodation was achieved by topical application of a muscarinic antagonist. Movements of the lens equator and the ciliary body were imaged during accommodation and disaccommodation using ultrasound biomicroscopy and goniovideography, and the images were analyzed to determine the direction and the extent of the movements.
Despite the systematic eye movements occurring with electrical stimulation and the nonsystematic eye movements occurring with pharmacologic stimulation, in all instances the ciliary body and the lens equator moved away from the sclera during accommodation.
Movement of the accommodative structures is consistent with the classic mechanism of accommodation described by Helmholtz, and contrary to that recently proposed by Schachar.
鉴于最近提出的灵长类动物新型调节机制以及随之而来的用于逆转老花眼的有争议的外科手术，利用猴子研究灵长类动物的调节机制。
实验研究。
通过手术植入中脑的电极刺激以及眼部局部应用毒蕈碱激动剂来诱导调节。通过局部应用毒蕈碱拮抗剂实现药物性去调节。在调节和去调节过程中，使用超声生物显微镜和前房角录像术对晶状体赤道和睫状体的运动进行成像，并对图像进行分析以确定运动的方向和程度。
尽管电刺激时会出现有规律的眼球运动，药物刺激时会出现无规律的眼球运动，但在所有情况下，调节时睫状体和晶状体赤道均远离巩膜。
调节结构的运动与亥姆霍兹描述的经典调节机制一致，与沙查尔最近提出的机制相反。
