Sakai K, Koike G, Seguchi K, Nakazato Y
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Brain Tumor Pathol. 1998;15(2):63-9. doi: 10.1007/BF02478885.
An exceptional case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) arising from the meninges in a 60-year-old Japanese man is presented. Computerized tomographic scans and magnetic resonance images demonstrated well-circumscribed tumorous lesions that were homogeneously enhanced with contrast medium. Systemic examination revealed no abnormalities except for a cervical lymphadenopathy and diabetes mellitus. Microscopic examination of the resected specimens showed proliferated histiocytosis and infiltration of plasma cells and lymphocytes. The histology was characterized by the presence of histiocytes demonstrating lymphophagocytosis and immunoreactivity for S-100 protein staining. Immunohistochemical studies and electron microscopy were useful in confirming the diagnosis. The clinical and histopathological features of this disease are discussed.
本文报告了一例60岁日本男性发生于脑膜的Rosai-Dorfman病（伴巨大淋巴结病的窦组织细胞增生症）的罕见病例。计算机断层扫描和磁共振成像显示边界清晰的肿瘤性病变，增强造影剂后呈均匀强化。全身检查除颈部淋巴结病和糖尿病外未发现异常。对切除标本的显微镜检查显示组织细胞增生以及浆细胞和淋巴细胞浸润。组织学特征为存在显示噬淋巴细胞现象且对S-100蛋白染色呈免疫反应性的组织细胞。免疫组织化学研究和电子显微镜检查有助于确诊。本文讨论了该疾病的临床和组织病理学特征。
