Sasaki H, Ikedo D, Kataoka M, Kido J, Kitamura S, Nagata T
Sasaki Dental Clinic, Naruto, Tokushima, Japan.
J Periodontol. 1999 Apr;70(4):445-8. doi: 10.1902/jop.1999.70.4.445.
Phenytoin, an anticonvulsant drug for epileptic patients, has many adverse effects, including calvarial thickening and coarsening of the facial features. Previous studies have demonstrated that phenytoin has an anabolic action on bone cells. This report describes pronounced palatal and mandibular tori found in a 45-year-old Japanese man undergoing chronic phenytoin therapy. The tori were extremely large, lobular, and symmetrical. A palatal torus appeared along the middle of the hard palate and mandibular tori consisted of 2 pairs of nodular masses extensively filling the lingual floor of the oral cavity. Pronounced osseous outgrowth occurred for the duration of a dose-increase of phenytoin from 1985 to 1997. His parents did not have any palatal or mandibular tori. These facts suggest that these unusual tori may have been the result of chronic phenytoin therapy, rather than association with the familial background.
苯妥英钠是一种用于癫痫患者的抗惊厥药物，有许多不良反应，包括颅骨增厚和面部特征变粗。先前的研究表明苯妥英钠对骨细胞有合成代谢作用。本报告描述了一名45岁接受慢性苯妥英钠治疗的日本男性患者出现的明显的腭隆突和下颌隆突。这些隆突非常大，呈小叶状且对称。一个腭隆突出现在硬腭中部，下颌隆突由两对结节状肿块组成，广泛填充口腔舌侧底部。在1985年至1997年苯妥英钠剂量增加期间出现了明显的骨质增生。他的父母没有任何腭隆突或下颌隆突。这些事实表明，这些异常的隆突可能是慢性苯妥英钠治疗的结果，而非与家族背景有关。
