暴露于α-肾上腺素能刺激下的大鼠腮腺碎片中磷脂酰肌醇标记增强。
Enhanced phosphatidylinositol labelling in rat parotid fragments exposed to alpha-adrenergic stimulation.
作者信息
Michell R H, Jones L M
出版信息
Biochem J. 1974 Jan;138(1):47-52. doi: 10.1042/bj1380047.
Abstract
- Adrenergic agonists provoke a marked increase in labelling of phosphatidylinositol in fragments of rat parotid gland. 2. Adrenaline and phenylephrine (an adrenergic alpha-agonist) are effective stimulants, but isoprenaline (an adrenergic beta-agonist) is relatively ineffective. 3. The response evoked by phenylephrine or adrenaline is prevented by prior incubation of the tissue with phenoxybenzamine (an alpha-receptor blocking agent), but not by prior incubation with pindolol (a beta-receptor blocking agent). 4. Adrenergic stimulation of phosphatidylinositol metabolism in parotid gland is therefore mediated through alpha-receptors, in common with the adrenaline-induced K(+) efflux. It is not linked to enzyme secretion, which is triggered by stimulation of beta-receptors. 5. It is suggested that the stimulation of phospholipid metabolism that occurs in several other tissues in the presence of adrenaline or noradrenaline may also involve alpha-receptors.
摘要
- 肾上腺素能激动剂可使大鼠腮腺组织碎片中的磷脂酰肌醇标记显著增加。2. 肾上腺素和去氧肾上腺素（一种肾上腺素能α激动剂）是有效的刺激物，但异丙肾上腺素（一种肾上腺素能β激动剂）相对无效。3. 用酚苄明（一种α受体阻断剂）预先孵育组织可阻止去氧肾上腺素或肾上腺素引起的反应，但用吲哚洛尔（一种β受体阻断剂）预先孵育则不能。4. 因此，腮腺中肾上腺素能刺激磷脂酰肌醇代谢是通过α受体介导的，这与肾上腺素诱导的钾离子外流相同。它与由β受体刺激引发的酶分泌无关。5. 有人提出，在肾上腺素或去甲肾上腺素存在下，其他几种组织中发生的磷脂代谢刺激也可能涉及α受体。
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