Kuwahara M, Suzuki A, Tsutsumi H, Tanigawa M, Tsubone H, Sugano S
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan.
Lab Anim Sci. 1999 Apr;49(2):202-8.
The purpose of the study was to document diurnal variation of autonomic nervous functions by use of power spectral analysis of heart rate (HR) variability.
To clarify characteristics of power spectral analysis of HR variability, electrocardiogram (ECG), blood pressure (BP), and respiratory (Resp) waveform simultaneously were recorded.
Two major spectral components were examined at low (LF)- and high (HF)-frequency bands for HR variability. Coherence between HR and Resp variabilities and HR and BP variabilities was maximal at approximately 0.14 and 0.03 Hz, respectively. On the basis of these data, two frequency bands of interest--LF (0.01 to 0.07 Hz) and HF (0.07 to 1.0 Hz)--were defined. Autonomic blockade studies indicated that the parasympathetic system mediated the HF and LF components, whereas the sympathetic system mediated only the LF component; HR had a diurnal pattern. The LF and HF bands in the dark phase tended to be higher than those in the light phase. The LF-to-HF ratio had a diurnal pattern similar to that of the HR.
Parasympathetic nervous activity in miniature swine may be predominant in the dark phase. The characteristics of power spectra and diurnal variations of autonomic nervous functions are almost the same as those of humans. Therefore, miniature swine may be a useful animal model for future biobehavioral and pharmacotoxicologic studies.
本研究的目的是通过心率（HR）变异性的功率谱分析记录自主神经功能的昼夜变化。
为阐明HR变异性功率谱分析的特征，同时记录心电图（ECG）、血压（BP）和呼吸（Resp）波形。
在HR变异性的低频（LF）和高频（HF）频段检查了两个主要频谱成分。HR与Resp变异性以及HR与BP变异性之间的相干性分别在约0.14和0.03Hz时最大。基于这些数据，定义了两个感兴趣的频段——LF（0.01至0.07Hz）和HF（0.07至1.0Hz）。自主神经阻滞研究表明，副交感神经系统介导HF和LF成分，而交感神经系统仅介导LF成分；HR具有昼夜模式。暗期的LF和HF频段往往高于明期。LF与HF比值具有与HR相似的昼夜模式。
小型猪的副交感神经活动在暗期可能占主导。自主神经功能的功率谱特征和昼夜变化与人类几乎相同。因此，小型猪可能是未来生物行为学和药物毒理学研究的有用动物模型。
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