Ishii K, Kuwahara M, Tsubone H, Sugano S
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
Lab Anim. 1996 Oct;30(4):359-64. doi: 10.1258/002367796780739880.
We have studied the autonomic nervous function in voles (Microtus arvalis) and mice. For this purpose, ECGs were recorded from conscious and unrestrained voles and mice using radiotelemetry and the autonomic nervous function was investigated by the power spectral analysis of heart rate variability. Heart rate in voles was lower than mice and the coefficient of variance was larger in voles. In the power spectra of voles and mice, there were two major spectral components with the high frequency (HF) peak generally appearing between 2.0 and 4.0 Hz, and the low frequency (LF) peak appearing below 0.6 Hz. On the basis of this data, we set the two frequency bands as LF (0.1-1.0 Hz) and HF (1.0-5.0 Hz) to evaluate autonomic nervous function. The LF and HF powers were larger in voles than mice. The LF/HF ratio was thought to provide a convenient index of autonomic nervous balance and was smaller in voles than mice. The LF powers in both species were reduced by atropine, but propranolol reduced the LF power only in mice. The HF power was reduced by atropine only in voles. The intrinsic heart rate produced by a double blockade with atropine and propranolol in voles was almost the same as control levels, but in mice was lower than controls. The ratio of the LF and HF powers by a double blockade were almost the same as those of the administration of atropine in voles, but nearer to propranolol in mice. These results suggested that the parasympathetic nervous function was predominant in voles, but the sympathetic one was predominant in mice.
我们研究了田鼠（草原田鼠）和小鼠的自主神经功能。为此，使用无线电遥测技术从清醒且不受束缚的田鼠和小鼠身上记录心电图，并通过心率变异性的功率谱分析来研究自主神经功能。田鼠的心率低于小鼠，且田鼠的方差系数更大。在田鼠和小鼠的功率谱中，有两个主要的频谱成分，高频（HF）峰值通常出现在2.0至4.0赫兹之间，低频（LF）峰值出现在0.6赫兹以下。基于这些数据，我们将两个频段设定为低频（0.1 - 1.0赫兹）和高频（1.0 - 5.0赫兹）以评估自主神经功能。田鼠的低频和高频功率均大于小鼠。低频/高频比值被认为是自主神经平衡的一个便捷指标，田鼠的该比值小于小鼠。两种动物的低频功率都因阿托品而降低，但普萘洛尔仅使小鼠的低频功率降低。高频功率仅在田鼠中因阿托品而降低。田鼠经阿托品和普萘洛尔双重阻断后产生的固有心率与对照水平几乎相同，但小鼠的固有心率低于对照。田鼠经双重阻断后的低频和高频功率比值与给予阿托品时几乎相同，但小鼠的该比值更接近普萘洛尔给药后的情况。这些结果表明，副交感神经功能在田鼠中占主导，但交感神经功能在小鼠中占主导。
