印度高剂量口服伤寒灭活疫苗的对照现场试验。
Controlled field trial of a high-dose oral killed typhoid vaccine in India.
作者信息
Chuttani C S, Prakash K, Gupta P, Grover V, Kumar A
出版信息
Bull World Health Organ. 1977;55(5):643-4.
A controlled field trial of a modified vaccine containing Salmonella typhi, TY 2 strain, in a dose of 400 x 10(9) killed organisms per capsule, was carried out in schoolchildren aged 6-17 years. The children were followed up for 6-8 months. There were 66 cases of typhoid fever in the vaccine group (7312 children) and 54 in the control group (7292 children who had received a placebo). This difference is not statistically significant. The results confirm that, as found in earlier trials, oral typhoid vaccine, in the dosages used so far, gives no protection.
对一种改良疫苗进行了一项对照现场试验，该疫苗含有伤寒沙门氏菌TY 2菌株，每粒胶囊含400×10⁹个灭活菌体，试验对象为6至17岁的学童。对这些儿童进行了6至8个月的随访。疫苗组（7312名儿童）有66例伤寒热病例，对照组（7292名接受安慰剂的儿童）有54例。这种差异无统计学意义。结果证实，正如早期试验所发现的那样，迄今为止使用的口服伤寒疫苗没有提供保护作用。
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