Wolfe F
Arthritis Research Center and University of Kansas School of Medicine, Wichita 67214, USA.
J Rheumatol. 1999 May;26(5):1172-5.
To ascertain if the symptom content and rate of symptoms in patients with fibromyalgia (FM) are similar to those in what has been called silicone implant associated syndrome (SIAS), and to determine if SIAS is indeed a new disease or whether it is largely recognizable as FM.
Mailed survey to 901 patients in Wichita, KS, Portland, OR, Los Angeles, CA, Peoria, IL, Boston, MA, San Antonio, TX, and eastern Kansas who were participating in a longterm outcome study of FM. Laboratory data were available from Wichita patients.
Content of symptoms was similar to that in SIAS, and rates were generally as high or higher in patients with FM than in SIAS. In patients with FM, 37.2% had all of the following 5 items: arthralgias, myalgias, sicca complex, atypical rash, and symptoms of a peripheral neuropathy; and 55.2% had 4 of the 5 items.
These data do not suggest that SIAS is an unrecognized new disease, but suggest the opposite, that such symptoms are well known and previously recognized, and are common among those with musculoskeletal complaints and those seen in rheumatology clinics.
确定纤维肌痛（FM）患者的症状内容和症状发生率是否与所谓的硅酮植入相关综合征（SIAS）患者相似，并确定SIAS是否确实是一种新疾病，或者它在很大程度上是否可被识别为FM。
向堪萨斯州威奇托、俄勒冈州波特兰、加利福尼亚州洛杉矶、伊利诺伊州皮奥里亚、马萨诸塞州波士顿、得克萨斯州圣安东尼奥以及堪萨斯州东部参与FM长期预后研究的901名患者邮寄调查问卷。威奇托的患者可获取实验室数据。
症状内容与SIAS相似，FM患者的症状发生率通常与SIAS患者相同或更高。在FM患者中，37.2%有以下全部5项症状：关节痛、肌痛、干燥综合征、非典型皮疹和周围神经病变症状；55.2%有5项中的4项。
这些数据并不表明SIAS是一种未被认识的新疾病，而是表明相反的情况，即这些症状是众所周知且先前已被认识的，在有肌肉骨骼症状的患者以及在风湿病诊所就诊的患者中很常见。
