Boulanger D, Schneider D, Chippaux J P, Sellin B, Capron A
Centre de Recherche sur les Méningites et Schistosomoses (CERMES/OCCGE/ORSTOM), WHO Collaborating Centre for the Control of Schistosomosis, Niamey, Niger.
Int J Parasitol. 1999 Mar;29(3):415-8. doi: 10.1016/s0020-7519(98)00222-7.
The economic importance of the trematode Schistosoma bovis in African livestock has justified the development of a specific vaccine. Administered preventively to sheep, rSb28GST--the only molecule cloned from S. bovis which has demonstrated vaccine potentialities in goats and cattle--reduced the mean worm burden in vaccinated animals and improved their health status compared with that of non-vaccinated controls. As in goats, but not in bovines, the fecundity of the settled worm pairs was not modified. Therefore, rSb28GST can be proposed as a universal tool for the prevention of clinical disorders engendered by the main schistosome species affecting domestic ruminants in the African continent.
牛血吸虫这种吸虫对非洲家畜具有重要经济意义，这使得开发一种特异性疫苗成为必要。预防性接种给绵羊的rSb28GST（这是从牛血吸虫中克隆出的唯一一种在山羊和牛身上显示出疫苗潜力的分子），与未接种疫苗的对照组相比，降低了接种动物体内的平均虫负荷，并改善了它们的健康状况。与山羊一样，但与牛不同的是，定居虫对的繁殖力没有改变。因此，rSb28GST可作为一种通用工具，用于预防由影响非洲大陆家养反刍动物的主要血吸虫种类引起的临床疾病。
