Alper K R
Brain Research Laboratories, New York University School of Medicine, New York 10016, USA.
J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21. doi: 10.1176/jnp.11.2.209.
The author presents the hypothesis that reduced delta EEG power observed in cocaine withdrawal is related to changes in dopamine (DA) transmission related to cocaine sensitization. Evidence for this hypothesis includes the topographic anatomical correspondence between the putative site of delta generation and the cortical terminal field of the mesotelencephalic DA system, as well as the laminar distribution and ultrastructural features of DA terminals in frontal cortex that appear to be adapted to the modulation of the delta rhythm, a global forebrain EEG mode. The effect of DA on membrane conductances of individual pyramidal neurons also suggests that DA exerts a significant influence on delta power by modulating the transition between global and local EEG modes. Access to a neural correlate of sensitization via noninvasive EEG methodology could be useful in investigating the relationship of stimulant sensitization to the clinical syndrome of cocaine dependence.
作者提出了一个假说，即可卡因戒断时观察到的δ脑电图功率降低与可卡因致敏相关的多巴胺（DA）传递变化有关。这一假说的证据包括δ波产生的假定部位与中脑边缘DA系统的皮质终末场之间的地形解剖对应关系，以及额叶皮质中DA终末的层状分布和超微结构特征，这些特征似乎适应于对δ节律（一种全脑脑电图模式）的调节。DA对单个锥体神经元膜电导的影响也表明，DA通过调节全脑和局部脑电图模式之间的转换，对δ功率产生显著影响。通过非侵入性脑电图方法获得致敏的神经关联，可能有助于研究兴奋剂致敏与可卡因依赖临床综合征之间的关系。
