Lobanov A V, Barban P S, Misenzhnikov A V
Zh Mikrobiol Epidemiol Immunobiol. 1978 Nov(11):103-6.
The authors studied a possibility of using the antigen neutralization test with dry immunoglobulin typhus erythrocytic diagnostic agent for the purpose of detection of Rickettsia prowazeki antibodies. Blood sera of 315 healthy persons, 24 patients with sporadic typhus, and 18 laboratory animals immunized with R. sibirica and R. burneti, as well as with Proteus OX19 were examined. The results obtained pointed to the high specificity and sensitivity of the given serological test. A possibility of its use for antibody detection both in the typhus patients and in persons who sustained this infection in the past was demonstrated. In difference from the complement fixation test it permits to study anticomplementary sera.
作者研究了使用干燥免疫球蛋白斑疹伤寒红细胞诊断剂进行抗原中和试验以检测普氏立克次体抗体的可能性。对315名健康人、24名散发性斑疹伤寒患者以及18只接种西伯利亚立克次体、伯氏立克次体以及变形杆菌OX19的实验动物的血清进行了检测。所得结果表明该血清学检测具有高特异性和高敏感性。证明了其可用于检测斑疹伤寒患者以及既往感染过该疾病的人群体内的抗体。与补体结合试验不同，它能够检测抗补体血清。
