Kaufman H E, Varnell E D, Thompson H W
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, USA.
Am J Ophthalmol. 1999 May;127(5):531-6. doi: 10.1016/s0002-9394(99)00089-6.
To determine whether topically applied latanoprost increases the severity of acute herpes simplex keratitis, the rate of recurrence of herpes keratitis, or both, in the rabbit.
To determine the effect on severity of acute herpetic keratitis, the corneas of New Zealand white rabbits were infected with either the less-corticosteroid-sensitive McKrae strain or the corticosteroid-sensitive F(MP)E strain of herpes simplex virus type 1. Rabbits were randomly assigned to twice-a-day treatment with latanoprost 0.005%, dexamethasone sodium phosphate 0.1%, or balanced saline solution within 3 days of infection and evaluated daily for up to 13 days after infection. The severity of keratitis was graded in a masked manner. To determine the effect on recurrences of herpetic keratitis, animals infected with McKrae strain herpes simplex virus type 1 that survived to day 32 after infection were randomized to treatment with latanoprost 0.005% or balanced saline solution and evaluated for the presence of corneal lesions from postinfection day 32 to day 47.
In the severity studies, treatment of F(MP)E-infected corneas with latanoprost or dexamethasone significantly worsened herpetic keratitis; by postinfection day 5, F(MP)E-infected eyes treated with dexamethasone or latanoprost demonstrated significantly higher severity scores than the eyes treated with balanced saline solution (P = .0001 and .008, respectively). Scores of McKrae-infected corneas treated with latanoprost or dexamethasone were not significantly different from scores of balanced saline solution-treated corneas. In the recurrence study, treatment with latanoprost significantly increased the appearance of clinical recurrences in McKrae-infected eyes, compared with balanced saline solution treatment (P = .0064).
Latanoprost may worsen acute herpetic keratitis in the rabbit eye and increase the risk of recurrences in latently infected animals.
确定局部应用拉坦前列素是否会增加兔急性单纯疱疹性角膜炎的严重程度、疱疹性角膜炎的复发率，或两者均增加。
为确定对急性疱疹性角膜炎严重程度的影响，将新西兰白兔的角膜用对皮质类固醇敏感性较低的McKrae株或对皮质类固醇敏感的1型单纯疱疹病毒F(MP)E株感染。在感染后3天内，将兔子随机分配为每日两次用0.005%拉坦前列素、0.1%地塞米松磷酸钠或平衡盐溶液治疗，并在感染后长达13天内每天进行评估。以盲法对角膜炎的严重程度进行分级。为确定对疱疹性角膜炎复发的影响，将感染McKrae株1型单纯疱疹病毒且存活至感染后第32天的动物随机分为用0.005%拉坦前列素或平衡盐溶液治疗，并在感染后第32天至第47天评估角膜病变的存在情况。
在严重程度研究中，用拉坦前列素或地塞米松治疗F(MP)E感染的角膜会使疱疹性角膜炎显著恶化；在感染后第5天，用地塞米松或拉坦前列素治疗的F(MP)E感染眼的严重程度评分显著高于用平衡盐溶液治疗的眼（分别为P = 0.0001和0.008）。用拉坦前列素或地塞米松治疗的McKrae感染角膜的评分与用平衡盐溶液治疗的角膜评分无显著差异。在复发研究中，与用平衡盐溶液治疗相比，用拉坦前列素治疗显著增加了McKrae感染眼中临床复发的出现率（P = 0.0064）。
拉坦前列素可能会使兔眼急性疱疹性角膜炎恶化，并增加潜伏感染动物复发的风险。
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