Gustavsson P, Reuterwall C, Sadigh J, Söderholm M
Department of Occupational Health, Karolinska Hospital, Stockholm, Sweden.
Cancer Causes Control. 1999 Feb;10(1):59-64. doi: 10.1023/a:1008892830922.
To investigate cancer incidence and mortality among laboratory employees.
Mortality and cancer incidence were investigated among 2553 female and male laboratory workers employed at the Karolinska Institute and Karolinska Hospital in Stockholm between 1950 and 1989. Mortality was followed from 1952-1993 and cancer incidence from 1958-1992. Expected numbers were based on the general population in Stockholm, standardizing for age, gender, and calendar period.
The overall mortality and cancer incidence in the cohort was lower than expected. There were in all 10 cases of hemato-lymphatic malignancies (three acute myeloid leukemias, four non-Hodgkin lymphomas, two Hodgkin's lymphomas, and one multiple myeloma) in the cohort. The standardized incidence ratio (SIR) for hematolymphatic tumors was increased among workers who had ever been employed in laboratories with a high probability for chemical exposure, SIR 224 (95% CI 108-412). The risk of breast cancer among women was increased after more than 10 years of work in high-exposure laboratories, SIR 225 (128-365). The number of malignant melanomas exceeded those expected.
The findings support earlier observations of an increased risk of hematolymphatic cancer among laboratory workers. The routine for handling chemicals and functionality of ventilatory equipment must be under continuous supervision.
调查实验室工作人员的癌症发病率和死亡率。
对1950年至1989年期间受雇于斯德哥尔摩卡罗林斯卡学院和卡罗林斯卡医院的2553名男女实验室工作人员的死亡率和癌症发病率进行调查。死亡率随访时间为1952年至1993年，癌症发病率随访时间为1958年至1992年。预期数字基于斯德哥尔摩的普通人群，并根据年龄、性别和日历时间进行标准化。
该队列的总体死亡率和癌症发病率低于预期。该队列中共有10例血液淋巴系统恶性肿瘤（3例急性髓性白血病、4例非霍奇金淋巴瘤、2例霍奇金淋巴瘤和1例多发性骨髓瘤）。在曾在化学暴露可能性高的实验室工作过的工人中，血液淋巴肿瘤的标准化发病比（SIR）有所增加，SIR为224（95%CI 108 - 412）。在高暴露实验室工作超过10年的女性患乳腺癌的风险增加，SIR为225（128 - 365）。恶性黑色素瘤的数量超过预期。
这些发现支持了早期关于实验室工作人员血液淋巴癌风险增加的观察结果。化学品处理流程和通风设备的功能必须持续受到监督。
