Boniol M, Koechlin A, Sorahan T, Jakobsson K, Boyle P
University of Strathclyde Institute of Global Public Health, Lyon, France.
International Prevention Research Institute, iPRI, Lyon, France.
Occup Environ Med. 2017 Jun;74(6):417-421. doi: 10.1136/oemed-2016-103989. Epub 2017 Jan 6.
Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK.
Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence ratios (SIRs), based on country-specific and period-specific incidence rates, were analysed for all cancers combined (except non-melanoma skin), bladder, lung, stomach cancer, leukaemia, non-Hodgkin's lymphoma and multiple myeloma. Exploratory analyses were conducted for other cancers with a minimum of 10 cases in both genders combined.
16 026 individuals (12 441 men; 3585 women) contributed to 397 975 person-years of observation, with 846 cancers observed overall (437 in the UK, 409 in Sweden). No statistically significant increased risk was observed for any site of cancer. A reduced risk was evident for all cancers combined (SIR=0.83, 95% CI (0.74 to 0.92)), lung cancer (SIR=0.74, 95% CI (0.59 to 0.93)), non-Hodgkin's lymphoma (SIR=0.67, 95% CI (0.45 to 1.00)) and prostate cancer (SIR=0.77, 95% CI (0.64 to 0.92)). For stomach cancer and multiple myeloma, SIRs were 0.93 (95% CI (0.61 to 1.43)) and 0.92 (95% CI 0.44 to 1.91), respectively. No increased risk of bladder cancer was observed (SIR=0.88, 95% CI (0.61 to 1.28)).
No significantly increased risk of cancer incidence was observed in the combined cohort of rubber workers first employed since 1975. Continued surveillance of the present cohorts is required to confirm absence of long-term risk and confirmatory findings from other cohorts would be important.
有报告称，20世纪60年代以前受雇于橡胶制造业的工人患癌风险增加，但后来受雇的工人情况尚不清楚。本研究聚焦于1975年后首次受雇于瑞典和英国的橡胶工人的癌症发病率。
分析了两组至少工作1年的橡胶工人队列。基于特定国家和特定时期发病率的标准化发病比（SIR），对所有癌症（非黑色素瘤皮肤癌除外）、膀胱癌、肺癌、胃癌、白血病、非霍奇金淋巴瘤和多发性骨髓瘤进行了分析。对两性合计至少有10例病例的其他癌症进行了探索性分析。
16026人（12441名男性；3585名女性）参与了397975人年的观察，共观察到846例癌症（英国437例，瑞典409例）。未观察到任何癌症部位有统计学显著增加的风险。所有癌症合计（SIR=0.83，95%CI（0.74至0.92））、肺癌（SIR=0.74，95%CI（0.59至0.93））、非霍奇金淋巴瘤（SIR=0.67，95%CI（0.45至1.00））和前列腺癌（SIR=0.77，95%CI（0.64至0.92））的风险降低。胃癌和多发性骨髓瘤的SIR分别为0.93（95%CI（0.61至1.43））和0.92（95%CI 0.44至1.91）。未观察到膀胱癌风险增加（SIR=0.88，95%CI（0.61至1.28））。
在1975年以来首次受雇的橡胶工人合并队列中，未观察到癌症发病率有显著增加的风险。需要对当前队列进行持续监测，以确认不存在长期风险，其他队列的验证性结果也将很重要。
