de Roos N M, Schouten G, Katan M B
Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, The Netherlands.
Eur J Clin Nutr. 1999 Apr;53(4):277-80. doi: 10.1038/sj.ejcn.1600722.
To investigate whether intake of Lactobacillus acidophilus strain L-1 lowers serum cholesterol in healthy men and women.
Randomised, placebo-controlled parallel trial.
Subjects were free-living. Blood sampling and distribution of yoghurts were administered at a local hospital.
Seventy-eight adult men and women with cholesterol levels of 3.9-7.8 mmol/L (mean +/- s.d., 5.4+/-0.7).
Subjects consumed 500 mL of control yoghurt daily for two weeks. They were then randomly allocated to receive 500 mL per day of control yoghurt or of yoghurt enriched with Lactobacillus acidophilus L-1 for another six weeks. The yoghurts were spiked with a trace of lithium; compliance as assessed by plasma lithium was excellent.
Energy and nutrient intake was constant, and identical for the two groups. Mean body weight was stable. Baseline blood lipid concentrations in the control and treatment groups were highly similar. The effect of consumption of Lactobacillus acidophilus L-1 vs. control on total cholesterol was -0.02 mmol/L (95% CI, -0.18-0.15) after three weeks and 0.04 mmol/L (95% CI, -0.12-0.20) after six weeks. Serum LDL and HDL-cholesterol and triacylglycerol levels were also unaffected.
Yoghurt enriched with Lactobacillus acidophilus L-1 does not lower serum cholesterol in men and women with normal to borderline high cholesterol levels.
研究摄入嗜酸乳杆菌L-1菌株是否能降低健康男性和女性的血清胆固醇水平。
随机、安慰剂对照平行试验。
受试者为自由生活状态。血液采样和酸奶分发在当地一家医院进行。
78名成年男性和女性，胆固醇水平为3.9 - 7.8 mmol/L（均值±标准差，5.4±0.7）。
受试者连续两周每天食用500 mL对照酸奶。然后将他们随机分为两组，一组继续每天食用500 mL对照酸奶，另一组每天食用富含嗜酸乳杆菌L-1的酸奶，持续六周。酸奶中添加了微量锂；通过血浆锂评估的依从性极佳。
两组的能量和营养摄入保持恒定且相同。平均体重稳定。对照组和治疗组的基线血脂浓度高度相似。食用嗜酸乳杆菌L-1酸奶与对照酸奶相比，三周后总胆固醇的变化为 -0.02 mmol/L（95%可信区间，-0.18 - 0.15），六周后为0.04 mmol/L（95%可信区间，-0.12 - 0.20）。血清低密度脂蛋白和高密度脂蛋白胆固醇以及三酰甘油水平也未受影响。
对于胆固醇水平正常至临界偏高的男性和女性，富含嗜酸乳杆菌L-1的酸奶不能降低血清胆固醇水平。
