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[从事粉尘农药生产的化工厂工人的支气管高反应性]

[Bronchial hyperreactivity in chemical plant workers employed in the production of dust pesticides].

作者信息

Kossmann S, Pierzchała W, Hefczyc J

机构信息

II Katedry i Kliniki Chorób Wewnetrznych Slaskiej Akademii Medycznej w Katowicach.

出版信息

Wiad Lek. 1999;52(1-2):25-9.

PMID:10335121
Abstract

The staff of two chemical plant divisions producing dust pesticides, 131 employees exposed to dust containing 28-65% SiO2 at an average dust concentration of 4.8-5.2 mg/m3 were examined. In the first division (group I, 38 males and 35 females) captan, carbamates, dodine and chlorinated hydrocarbons active substances. In the second division (group II, 26 males and 32 females) the active substances included: carbamates, triazine compounds, cupric oxychloride, captan, lindane, carboxine. Chronic bronchitis was diagnosed in 51.5% of males and 14.9% of females, none had history of asthma. Spirography showed frequent occurrence of impaired maximal endexpiratory flow and elevated residual volume; in about a quarter of the examined subjects a decreased one-second forced expiratory volume was found. The rate of bronchial hyperreactivity to histamine in the examined workers (group I-9.6%, group II-10.3%) did not differ significantly from the control group of 31 healthy inhabitants of the region, professionally unexposed to dust and chemical noxes (6.5%).

摘要

对两个生产含尘农药的化工厂部门的员工进行了检查,共131名员工,他们暴露于平均粉尘浓度为4.8 - 5.2毫克/立方米、含28 - 65%二氧化硅的粉尘环境中。在第一部门(第一组,38名男性和35名女性),活性物质有克菌丹、氨基甲酸酯类、多果定和氯代烃。在第二部门(第二组,26名男性和32名女性),活性物质包括:氨基甲酸酯类、三嗪化合物、氯氧化铜、克菌丹、林丹、萎锈灵。诊断出51.5%的男性和14.9%的女性患有慢性支气管炎,无人有哮喘病史。肺功能检查显示,最大呼气末流速受损和残气量升高的情况频繁出现;在约四分之一的受检者中,发现一秒用力呼气量降低。受检工人(第一组为9.6%,第二组为10.3%)对组胺的支气管高反应性发生率与该地区31名未从事粉尘和化学毒物职业暴露的健康居民对照组(6.5%)相比,差异无统计学意义。

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