Kossmann S, Tustanowski J, Kołodziej B
Kliniki Chorób Wewnetrznych i Farmakologii Klinicznej, Slaskiej Akademii Medycznej w Katowicach.
Med Pr. 2001;52(4):253-6.
The study covered workers of a chemical plant producing dust pesticides. A study group included 24 men, aged 29-54 years, employed directly in the production, and 22 women, aged 31-52 years, performing auxiliary jobs and handling only closed packages. In order to assess the renal function in the workers, the concentrations of serum creatinine and uric acid, protein, albumin and alpha 1-microglobulin, as well as the activity of alkaline phosphatase (AP) and N-acetyl-beta-glucosaminidase (NAG) in urine were determined. The average air dust concentration at the workplaces was 0.42-16.66 mg/m3. The active substances with concentrations ranging from 10 to 75% in the final product were as follows: triazines, dithiocarbamates, carbendazim and thiophanate-methyl, captan, phenylureas, cupric oxychloride and occasionally also carbamates, dodine and 2,4-D. As compared to the results in the control groups of 31 healthy men and 22 women, free from occupational exposure to chemical noxas, a significantly higher serum creatinine concentration (in none of the subjects creatinine concentration exceeded the upper normal limit) and higher urinary protein, albumin and alpha 1-microglobulin concentrations, and higher enzyme activity were found in men, while in women only urine enzyme activity was significantly increased. The results speak in support of a discreet subclinical kidney impairment.
该研究涵盖了一家生产含尘农药的化工厂的工人。研究组包括24名年龄在29至54岁之间、直接从事生产工作的男性，以及22名年龄在31至52岁之间、从事辅助工作且仅处理密封包装的女性。为了评估这些工人的肾功能，测定了血清肌酐、尿酸、蛋白质、白蛋白和α1 -微球蛋白的浓度，以及尿液中碱性磷酸酶（AP）和N -乙酰-β -氨基葡萄糖苷酶（NAG）的活性。工作场所的平均空气粉尘浓度为0.42至16.66毫克/立方米。最终产品中浓度范围为10%至75%的活性物质如下：三嗪类、二硫代氨基甲酸盐类、多菌灵和甲基托布津、克菌丹、苯基脲类、氧氯化铜，偶尔还有氨基甲酸盐类、多果定和2,4 - D。与31名未接触职业性化学毒物的健康男性和22名健康女性的对照组结果相比，发现男性的血清肌酐浓度显著更高（所有受试者的肌酐浓度均未超过正常上限），尿蛋白、白蛋白和α1 -微球蛋白浓度更高，酶活性也更高，而女性仅尿酶活性显著增加。这些结果支持存在轻微的亚临床肾损害。
