Goldring O L, Clegg J A, Smithers S R, Terry R J
Clin Exp Immunol. 1976 Oct;26(1):181-7.
Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human blood of various specificities and tested for the presence of blood group substances on their surfaces. The tests employed were survival following transfer into rhesus monkeys immunized against human blood substances, mixed agglutination reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at the surface when the parasites were cultured in blood of appropriate specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the parasite surface following culture. The evidence suggests that the expressed blood group antigens are of host origin and are acquired by the parasite during culture, probably in the form of glycolipids or megaloglycolipids. It is likely that these substances are also acquired by parasites in the bloodstream of man. They may serve to mask surface parasite antigens, and so enable schistosomes to evade parasite-specific humoral or cellular immune responses.
曼氏血吸虫的幼虫期（童虫）已在具有不同血型特异性的人血中培养，并检测其表面是否存在血型物质。所采用的检测方法包括将其转移至针对人血物质免疫的恒河猴体内后的存活情况、混合凝集反应以及免疫荧光法。当寄生虫在具有适当特异性的血液中培养时，其表面表达A、B、H和Lewisb+抗原。培养后，在寄生虫表面未检测到恒河猴、MNS和达菲抗原。证据表明，所表达的血型抗原源自宿主，寄生虫在培养过程中获得了这些抗原，可能是以糖脂或巨糖脂的形式。寄生虫很可能也会在人体血液中获得这些物质。它们可能有助于掩盖寄生虫表面抗原，从而使血吸虫能够逃避寄生虫特异性体液或细胞免疫反应。
