School of Medicine, Nantong University, Nantong, Jiangsu, PR China.
School of Medicine, Nantong University, Nantong, Jiangsu, PR China.
Infect Genet Evol. 2020 Oct;84:104485. doi: 10.1016/j.meegid.2020.104485. Epub 2020 Jul 30.
The COVID-19 spreads rapidly around the world which has brought a global health crisis. The pathogen of COVID-19 is SARS-COV-2, and previous studies have proposed the relationship between ABO blood group and coronavirus. Here, we aim to delve into the association between ABO blood group and COVID-19 infection, severity and demise.
The relevant studies were retrieved from five databases: PubMed, MedRxiv, BioRxiv,Web of Science and CNKI. Members of cases(symptomatic cases, severe cases, died cases) and controls(asymptomatic controls, non-severe controls, alive controls) were extracted from collected studies. Odds ratios (OR) and 95% confidence intervals (CI) were calculated and interpreted from extracted data. Publication bias and sensitivity analysis were also applied to confirm our discovery.
Overall 31,100 samples were included in the analysis. Compared to other ABO blood type, an increased odds of infecting COVID-19 among individuals with A blood group (OR: 1.249, 95%CI: 1.114-1.440, P < 0.001) and a decreased odds of infecting COVID-19 among individuals with blood group O (OR: 0.699, 95%CI: 0.635-0.770, P < 0.001) were found. Besides, individuals with blood group AB seems to link a higher risk to COVID-19 severity (OR: 2.424, 95%CI: 0.934-6.294) and demise (OR: 1.348, 95%CI: 0.507-3.583). Meantime, individuals with O blood group might had lower risk to COVID-19 severity (OR: 0.748, 95%CI: 0.556-1.007), and individuals with B blood group were likely to relate a lower risk to COVID-19 demise.
The current meta-analysis suggest that blood type A might be more susceptible to infect COVID-19 while blood type O might be less susceptible to infect COVID-19; there were no correlation between ABO blood group and severity or demise of COVID-19. However, more investigation and research are warranted to clarify the relationship between COVID-19 and ABO blood type.
COVID-19 在全球范围内迅速传播，引发了全球卫生危机。COVID-19 的病原体是 SARS-COV-2，先前的研究已经提出了 ABO 血型与冠状病毒之间的关系。在这里，我们旨在深入研究 ABO 血型与 COVID-19 感染、严重程度和死亡之间的关系。
从五个数据库：PubMed、MedRxiv、BioRxiv、Web of Science 和中国知网中检索相关研究。从收集的研究中提取病例（有症状病例、严重病例、死亡病例）和对照（无症状对照、非严重对照、存活对照）的成员。从提取的数据中计算并解释比值比（OR）和 95%置信区间（CI）。还应用了发表偏倚和敏感性分析来证实我们的发现。
共有 31100 个样本纳入分析。与其他 ABO 血型相比，A 型血个体感染 COVID-19 的几率更高（OR：1.249，95%CI：1.114-1.440，P<0.001），而 O 型血个体感染 COVID-19 的几率较低（OR：0.699，95%CI：0.635-0.770，P<0.001）。此外，AB 型血个体似乎与 COVID-19 严重程度（OR：2.424，95%CI：0.934-6.294）和死亡（OR：1.348，95%CI：0.507-3.583）的风险更高相关。同时，O 型血个体患 COVID-19 严重程度的风险较低（OR：0.748，95%CI：0.556-1.007），B 型血个体患 COVID-19 死亡的风险较低。
本荟萃分析表明，A型血可能更容易感染 COVID-19，而 O 型血可能不易感染 COVID-19；ABO 血型与 COVID-19 的严重程度或死亡无关。然而，需要更多的调查和研究来阐明 COVID-19 与 ABO 血型之间的关系。
