精胺敏感型核糖核酸酶S'的设计与半合成
Design and semisynthesis of spermine-sensitive Ribonuclease S'.
作者信息
Hamachi I, Yamada Y, Eboshi R, Hiraoka T, Shinkai S
机构信息
Department of Chemistry & Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki, Fukuoka, Japan.
出版信息
Bioorg Med Chem Lett. 1999 May 3;9(9):1215-8. doi: 10.1016/s0960-894x(99)00189-4.
Abstract
Spermine-sensitive stabilization of semisynthetic Ribonuclease S' was successfully carried out by sequence specific incorporation of a poly-anion domain into alpha-helix region of S-peptide.
摘要
通过将聚阴离子结构域序列特异性地掺入S肽的α-螺旋区域，成功实现了半合成核糖核酸酶S'的精胺敏感稳定化。
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