笼状核糖核酸酶：通过位点特异性掺入2-硝基苄基部分实现酶从完全关闭状态的光激活。
Caged RNase: photoactivation of the enzyme from perfect off-state by site-specific incorporation of 2-nitrobenzyl moiety.
作者信息
Hiraoka Takashi, Hamachi Itaru
机构信息
Institute for Fundamental Research of Organic Chemistry (IFOC), Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
出版信息
Bioorg Med Chem Lett. 2003 Jan 6;13(1):13-5. doi: 10.1016/s0960-894x(02)00825-9.
Abstract
Photo-triggered activation of semisynthetic Ribonuclease S' from a perfect off-state was successfully carried out by incorporation of photo-labile caged moiety into a proximity to the active site.
摘要
通过将光不稳定的笼蔽部分引入到接近活性位点的位置，成功实现了从完全关闭状态对半合成核糖核酸酶S'的光触发激活。
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