Wakakura M, Minei-Higa R, Oono S, Matsui Y, Tabuchi A, Kani K, Shikishima K, Kawai K, Nakao Y, Tazawa Y, Kiyosawa M, Abe H, Ohba N, Yago K, Maeda S, Sugita M, Ishikawa S
Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Japan.
Jpn J Ophthalmol. 1999 Mar-Apr;43(2):127-32. doi: 10.1016/s0021-5155(98)00072-0.
An optic neuritis treatment trial was conducted at 30 clinical centers in Japan using the same protocol. Patient participation was based on: age range of 14-55 years; acute symptoms indicative of unilateral optic neuritis of unknown or demyelinating origin; visual symptoms of 14-day duration or less; relative afferent pupillary defect in affected eye; and normal or swollen optic disc of affected eye.
Initially, 102 patients qualified for participation; baseline data were obtained for analysis from 70 of these patients. Demographic characteristics of Japanese patients with optic neuritis were clarified and compared with those in a US study.
The incidence of ocular or periocular pain and the presence of periventricular plaques were noted to be lower, and the incidence of disc swelling higher, in the Japanese patients, suggesting racial differences in the characteristics of the disease. Such differences may possibly be related to the lower incidence of multiple sclerosis in Japanese patients. The results of visual function tests were virtually the same in both studies. The nonaffected eyes of more than half the patients showed abnormal mean deviation in Humphrey field analysis, as also noted in the US study.
The baseline clinical features of optic neuritis in the Japanese patients have been defined. Some racial differences in the characteristics of the disease may exist.
在日本的30个临床中心按照相同方案进行了一项视神经炎治疗试验。患者入选标准为：年龄在14至55岁之间；有提示不明原因或脱髓鞘性单侧视神经炎的急性症状；视觉症状持续时间为14天或更短；患眼存在相对性传入瞳孔障碍；患眼视盘正常或肿胀。
最初，102例患者符合入选条件；从其中70例患者获取基线数据用于分析。明确了日本视神经炎患者的人口统计学特征，并与美国一项研究中的患者特征进行了比较。
日本患者眼痛或眼周疼痛的发生率以及脑室周围斑块的发生率较低，而视盘肿胀的发生率较高，提示该病特征存在种族差异。这种差异可能与日本患者多发性硬化症的较低发病率有关。两项研究中视觉功能测试的结果基本相同。超过半数患者的未患眼在Humphrey视野分析中显示平均偏差异常，美国的研究中也有此发现。
已明确日本患者视神经炎的基线临床特征。该病特征可能存在一些种族差异。
