Selim H M, Yamato O, Tajima M, Maede Y
Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
J Vet Med Sci. 1999 Apr;61(4):369-74. doi: 10.1292/jvms.61.369.
The mechanism of onion-induced hemolytic anemia in ruminants was investigated. The ether-extract obtained from the mixture of rumen fluid and onion juice incubated at 38.5 degrees C for 9 hr induced oxidative damage in sheep erythrocytes in vitro, indicating the production of certain oxidants in the mixture. The increase of the oxidative effect in the mixture was inhibited completely by the removal of rumen microorganisms and partly by treatment with antibiotics and by oxygen gas. The sheep fed onions (50 g/kg body weight/day) for 15 days developed more severe Heinz body hemolytic anemia than did the sheep fed the equivalent amount of onions with 5 g/day ampicillin sodium salt. The results indicated that certain rumen bacteria appear to be involved in the onset of onion-induced hemolytic anemia in sheep.
对反刍动物中洋葱诱导的溶血性贫血机制进行了研究。从瘤胃液和洋葱汁的混合物中获得的乙醚提取物在38.5℃孵育9小时后，在体外诱导绵羊红细胞发生氧化损伤，表明混合物中产生了某些氧化剂。通过去除瘤胃微生物，以及部分通过抗生素处理和氧气处理，混合物中的氧化作用增强被完全抑制。给绵羊喂食洋葱（50克/千克体重/天）15天，比给绵羊喂食等量洋葱并每天添加5克氨苄青霉素钠盐的情况，出现了更严重的海因茨小体溶血性贫血。结果表明，某些瘤胃细菌似乎参与了绵羊中洋葱诱导的溶血性贫血的发病过程。
