McGeoch D J, Davison A J
MRC Virology Unit, Church Street, Glasgow, G11 5JR, UK.
Semin Cancer Biol. 1999 Jun;9(3):201-9. doi: 10.1006/scbi.1999.0093.
Analysis of conserved herpesvirus genes shows that human herpesvirus 8 (HHV8) belongs to a clade of primate herpesviruses within the gamma2 sublineage. Overall, this clade has developed by cospeciation with host species. Seventeen genes of HHV8 and its nearest relatives lack simple homologues in other herpesviruses, and eight of these have known mammalian homologues, presumed to be the sources of the HHV8 versions. Comparative analyses yield further insights into the source or time of acquisition for several of these genes. All were acquired by the HHV8 lineage in the very distant past. Two unusual processes are manifest in the contemporary evolution of HHV8. First, the K1 gene is uniquely undergoing a process of extensive and positively selected substitution, of unknown significance. Secondly, the K15 gene has been substituted in some lineages by a distant homologue, presumably by recombination with an unknown herpesvirus. While available data are otherwise compatible with a cospeciational relationship between HHV8 and the human species, they do not exclude relatively recent transfer to humans from another primate host.
对保守的疱疹病毒基因的分析表明，人类疱疹病毒8型（HHV8）属于γ2亚谱系内的灵长类疱疹病毒进化枝。总体而言，该进化枝是通过与宿主物种共同物种形成而发展起来的。HHV8及其近亲的17个基因在其他疱疹病毒中缺乏简单的同源物，其中8个具有已知的哺乳动物同源物，推测是HHV8版本的来源。比较分析对其中几个基因的来源或获得时间有了进一步的了解。所有这些基因都是HHV8谱系在非常遥远的过去获得的。在HHV8的当代进化中表现出两个不寻常的过程。首先，K1基因正在经历一个广泛且正向选择替代的独特过程，其意义尚不清楚。其次，K15基因在一些谱系中被一个远亲同源物取代，推测是通过与一种未知疱疹病毒的重组。虽然现有数据在其他方面与HHV8和人类物种之间的共同物种形成关系相符，但它们并不排除相对较近期从另一种灵长类宿主转移到人类的可能性。
