Department of Biotechnology, Visva‑Bharati, (Central University), Bolpur, West Bengal 731235, India.
Department of Chemistry, Visva‑Bharati, (Central University), Bolpur, West Bengal 731235, India.
Int J Mol Med. 2022 Sep;50(3). doi: 10.3892/ijmm.2022.5173. Epub 2022 Jul 20.
Synthetic and modified natural derivatives are reported as potential bioactive compounds and are being used therapeutically against various diseases in a widespread manner nowadays. Cancerous cells exhibit high levels of reactive oxygen species (ROS) internally, and thus successfully manage to sustain themselves and proliferate via antioxidative mechanisms that maintain a redox balance. On this note, various antioxidants are applied as anticancer compounds, which strategically affects the ongoing oncogenic stress management system in both a pro‑ and antioxidative manner, resulting in cancer restriction, as well as sustaining cell proliferation via antioxidative mechanisms that promote cancer progression. Alike non‑viral cancers, viral cancers exhibit varying levels of ROS during different stages of cancer progression. Hence, successful stress balance should be addressed, depending on the cancer cell stress response during the therapeutic management. The application of antioxidants is crucial and needs to be carefully designed in such cases; the respective underlying mechanisms are less understood. The role of antioxidants controlling the varied levels of stress response at different stages of Kaposi's sarcoma‑associated herpes virus malignancy have not been fully reported. Therefore, the present study aimed to analyze the activity of certain antioxidants in KSHV‑infected oncogenic cells. For this purpose, two naturally derived flavonoid‑based antioxidants (theaflavin and novel curcumin derivatives) were selected and tested in different KSHV‑infected cell lines. The findings presented herein demonstrate that these compounds can successfully induce the death of different KSHV‑positive cells and can restrict the growth of KSHV‑infected cell lines restricting viral reactivation by counteracting the oncogenic stress management system.
合成和修饰的天然衍生物被报道为有潜力的生物活性化合物，如今正在被广泛地用于治疗各种疾病。癌细胞内部会产生高水平的活性氧（ROS），因此它们成功地通过抗氧化机制来维持自身的生存和增殖，从而保持氧化还原平衡。基于这一点，各种抗氧化剂被用作抗癌化合物，这些化合物以一种既促进又抑制的方式，战略性地影响正在进行的致癌应激管理系统，从而限制癌症的发展，并通过促进癌症进展的抗氧化机制来维持细胞增殖。与非病毒性癌症一样，病毒性癌症在癌症进展的不同阶段会表现出不同水平的 ROS。因此，应该根据治疗管理期间癌细胞的应激反应来成功地实现应激平衡。在这种情况下，抗氧化剂的应用至关重要，需要精心设计；相应的潜在机制还不太清楚。抗氧化剂控制卡波济肉瘤相关疱疹病毒恶性肿瘤不同阶段的应激反应水平的作用尚未得到充分报道。因此，本研究旨在分析某些抗氧化剂在 KSHV 感染的致癌细胞中控制应激反应的作用。为此，选择了两种天然衍生的基于类黄酮的抗氧化剂（茶黄素和新型姜黄素衍生物），并在不同的 KSHV 感染细胞系中进行了测试。本文的研究结果表明，这些化合物可以成功地诱导不同的 KSHV 阳性细胞死亡，并通过对抗致癌应激管理系统来限制 KSHV 感染细胞系的生长，从而限制病毒的重新激活。
