确定视网膜内层对人类多焦视网膜电图的贡献。

Identifying inner retinal contributions to the human multifocal ERG.

作者信息

Hood D C, Greenstein V, Frishman L, Holopigian K, Viswanathan S, Seiple W, Ahmed J, Robson J G

机构信息

Department of Psychology, Columbia University, New York, NY 10027, USA.

出版信息

Vision Res. 1999 Jun;39(13):2285-91. doi: 10.1016/s0042-6989(98)00296-x.

DOI:10.1016/s0042-6989(98)00296-x

PMID:10343810

Abstract

Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.

摘要

通过在玻璃体内注射 N-甲基-DL-天冬氨酸（NMDLA）和/或河豚毒素（TTX）前后对猴子进行记录，确定了来自视网膜内层（即神经节细胞和无长突细胞）对多焦视网膜电图（ERG）的贡献。如果将刺激对比度设置为 50%而不是通常采用的 100%对比度，则在人类多焦 ERG 中可识别出波形与被药物去除的成分相似的成分。在一些患有青光眼和糖尿病（影响视网膜内层的疾病）的患者的记录中，发现这些成分缺失或减少。