Zhou Wei, Rangaswamy Nalini, Ktonas Periklis, Frishman Laura J
College of Optometry, University of Houston, Houston, TX, USA.
Vision Res. 2007 Jul;47(15):2021-36. doi: 10.1016/j.visres.2007.03.021. Epub 2007 May 23.
This study used the Matching Pursuit (MP) method, a time-frequency analysis, to identify and characterize oscillatory potentials (OPs) in the primate electroretinogram (ERG). When the slow-sequence mfERG from the macular region of the retina was matched with Gabor functions, OPs were identified in two distinct bands: a high-frequency band peaking around 150 Hz that contributes to early OPs, and a low-frequency band peaking around 80 Hz that contributes to both early and late OPs. Pharmacological blockade and experimental glaucoma studies showed that the high-frequency OPs depend upon sodium-dependent spiking activity of retinal ganglion cells, whereas the low-frequency OPs depend primarily upon non-spiking activity of amacrine cells, and more distal retinal activity.
本研究采用匹配追踪(MP)方法,一种时频分析方法,来识别和表征灵长类动物视网膜电图(ERG)中的振荡电位(OPs)。当将来自视网膜黄斑区域的慢序列多焦视网膜电图(mfERG)与伽柏函数进行匹配时,在两个不同的频段中识别出了OPs:一个高频频段在150Hz左右达到峰值,它对早期OPs有贡献;一个低频频段在80Hz左右达到峰值,它对早期和晚期OPs均有贡献。药理学阻断和实验性青光眼研究表明,高频OPs依赖于视网膜神经节细胞的钠依赖性放电活动,而低频OPs主要依赖于无长突细胞的非放电活动以及更远端的视网膜活动。