Williams K L
Proteome Systems, North Ryde, Sydney, NSW, Australia.
Electrophoresis. 1999 Apr-May;20(4-5):678-88. doi: 10.1002/(SICI)1522-2683(19990101)20:4/5<678::AID-ELPS678>3.0.CO;2-R.
The third Siena proteomics conference held August 31-September 4, 1998, heralded a change in emphasis from technology development to using proteomics to assist in resolving biological questions. In this review, proteomics is placed in context with other major influences in the way discovery research is conducted in biology. The current status of genomics is examined in its broadest sense, including how such studies may influence the development of proteomics. It is suggested that we are entering a new phase in biology where information is no longer limiting and integration of different technologies is required to attack the big problems of biology. While much of the focus of funding bodies, both in the public and private sector, is on practical outcomes (new drugs, etc.), the new technologies are equally amenable to attacking long-standing fundamental challenges, such as cell division, cell patterning and morphogenesis.
1998年8月31日至9月4日召开的第三届锡耶纳蛋白质组学会议标志着重点从技术开发转向利用蛋白质组学协助解决生物学问题。在这篇综述中，蛋白质组学与生物学发现研究开展方式中的其他主要影响因素相结合进行阐述。从最广泛的意义上审视了基因组学的现状，包括此类研究如何可能影响蛋白质组学的发展。有人认为，我们正在进入生物学的一个新阶段，信息不再是限制因素，需要整合不同技术来攻克生物学的重大问题。虽然公共和私营部门的资助机构大多将重点放在实际成果（新药等）上，但这些新技术同样适用于应对长期存在的基本挑战，如细胞分裂、细胞模式形成和形态发生。
