Lorenzo S, Iglesias R, Paniagua E, Leiro J, Ubeira F M
Laboratorio de Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Parasitol Res. 1999 Jun;85(6):441-5. doi: 10.1007/s004360050575.
We analyzed the antigenicity of biotinyl enzymes contained in somatic extracts from Anisakis simplex and other parasite nematodes and show in this report that these molecules are an important source of cross-reactivity problems among these nematodes. Cross-reactivity was most pronounced among members of the superfamily Ascaridoidea. These results suggest that the presence of biotinyl enzymes in whole somatic extracts of A. simplex and other parasites may make serodiagnostic assays based on this kind of antigenic preparation unreliable.
我们分析了简单异尖线虫及其他寄生线虫的体细胞提取物中所含生物素化酶的抗原性，并在本报告中表明，这些分子是这些线虫之间交叉反应问题的一个重要来源。交叉反应在蛔总科成员中最为明显。这些结果表明，简单异尖线虫和其他寄生虫的全身体细胞提取物中存在生物素化酶，可能会使基于这种抗体制备的血清诊断检测不可靠。
